research&development

OUR RESEARCH and DEVELOPMENT

We aim to improve the quality of medical treatments in the Asia Pacific region. We focus on conducting researches in the areas of pharmacogenomics and personalized medicine. Based on the association studies between single nucleotide polymorphisms (SNPs) and drug efficacy, we develop molecular diagnostic tools to allow patients and doctors to make informed decisions prior to treatments.

Publications
 
Journal papers (*Corresponding author)
 
1. Eugene Lin and Hsien-Yuan Lane. (2015) Genome-wide association studies in pharmacogenomics of antidepressants. Pharmacogenomics (in press).
 
2. Eugene Lin and Shih-Jen Tsai. (2015) Genome-wide microarray analysis of gene expression profiling in major depression and antidepressant therapy. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2015 Feb 20. [Epub ahead of print].
 
3. Eugene Lin and Shih-Jen Tsai. (2015) Pharmacogenetics in methadone therapy. Current Pharmacogenomics and Personalized Medicine (in press).
 
4. Tun-Jen Hsiao and Eugene Lin*. (2014) The Pro12Ala polymorphism in the peroxisome proliferator-activated receptor gamma (PPARG) gene in relation to obesity and metabolic phenotypes in a Taiwanese population. Endocrine 2014 Sep 3. [Epub ahead of print].
 
5. Eugene Lin and Hsien-Yuan Lane. (2014) Genetic Association of the NDUFS1 Gene with Antipsychotic-Induced Weight Gain in Schizophrenia. Pharmacogenomics 15(4): 415-417.
 
6. Tun-Jen Hsiao and Eugene Lin*. (2014) Evaluation of the Glutamine 27 Glutamic Acid Polymorphism in the Adrenoceptor Beta 2 Surface Gene on Obesity and Metabolic Phenotypes in Taiwan. Journal of Investigative Medicine 62(2):310-5.
 
7. Tun-Jen Hsiao, Yuchi HwangHua-Mei Chang, and Eugene Lin*. (2014) Association of the rs6235 Variant in the Proprotein Convertase Subtilisin/Kexin Type 1 (PCSK1) Gene with Obesity and Related Traits in a Taiwanese Population. Gene 533(1): 32-7.
 
8. Hsien-Yuan Lane, Guochuan E. Tsai, and Eugene Lin*. (2013) Genetic Association of the Dopamine Receptor D3 (DRD3) Ser9Gly Polymorphism with a DRD3 Antagonist. Personalized Medicine 10(7): 631-632.
 
9. Tun-Jen Hsiao, Yuchi Hwang, Can-Hong Liu, Hua-Mei Chang, and Eugene Lin*. (2013) Association of the C825T Polymorphism in the GNB3 Gene with Obesity and Metabolic Phenotypes in a Taiwanese Population. Genes & Nutrition 8(1): 137-44.
 
10. Hsien-Yuan Lane, Guochuan E. Tsai, and Eugene Lin*. (2012) Assessing Gene-Gene Interactions in Pharmacogenomics. Molecular Diagnosis & Therapy 16(1): 15-27.
 
11. Ying-Jay Liou, Ya Mei Bai, Eugene Lin, Jen-Yeu Chen, Tzu-Ting Chen, Chen-Jee Hong, and Shih-Jen Tsai. (2012) Gene-Gene Interactions of the INSIG1 and INSIG2 in Metabolic Syndrome in Schizophrenic Patients Treated with Atypical Antipsychotics. The Pharmacogenomics Journal 12(1): 54-61.
 
12. Hsien-Yuan Lane, Guochuan E. Tsai, and Eugene Lin*. (2012) Rapid Antidepressant Effects of Ketamine on Circadian Gene Expression. Personalized Medicine 9(1): 15-16.
 
13. Chun-Hsiang Wang, Wan-Sheng Ke, and Eugene Lin*. (2012) Evaluation of the ENPP1 and PLIN Single Nucleotide Polymorphisms with Type 2 Diabetes in a Taiwanese Population: Evidence for Replication and Gene-Gene Interaction. Journal of Investigative Medicine 60(8): 1169-73.
 
14. Eugene Lin* (2012) Novel Drug Therapies and Diagnostics for Personalized Medicine and Nanomedicine in Genome Science, Nanoscience, and Molecular Engineering. Pharmaceutical Regulatory Affairs: Open Access 1:e116.
 
15. Eugene Lin* and Shih-Jen Tsai. (2012) Novel Diagnostics R&D for Public Health and Personalized Medicine in TaiwanCurrent State, Challenges and Opportunities. Current Pharmacogenomics and Personalized Medicine 10(3): 239-246.
 
16. Eugene Lin and Shih-Jen Tsai. (2011) Gene-Gene Interactions in a Context of Individual Variability in Antipsychotic Drug Pharmacogenomics. Current Pharmacogenomics and Personalized Medicine 9: 323-331.
 
17. Mei-Hung Chi, Sheng-Yu Lee, Hui-Hua Chang, Yen-Kuang Yang, Eugene Lin, and Po-See Chen. (2011) Comparison of Antidepressant Efficacy-related SNPs Among Taiwanese and Four Populations in the HapMap Database. Journal of the Formosan Medical Association 110(7): 478-82.
 
18. Chun-Hsiang Wang, Yuchi Hwang, and Eugene Lin*. (2010) Pharmacogenomics of Chronic Hepatitis C Therapy with Genome-Wide Association Studies. Journal of Experimental Pharmacology 2: 73-82.
 
19. Wan-Sheng Ke, Yuchi Hwang, and Eugene Lin*. (2010) Pharmacogenomics of Drug Efficacy in the Interferon Treatment of Chronic Hepatitis C using Classification Algorithms. Advances and Applications in Bioinformatics and Chemistry 3: 39-44.
 
20. Tun-Jen Hsiao, Lawrence Shih-Hsin Wu, Shih-Yi Huang, and Eugene Lin*. (2010) A Common Variant in the Adiponectin Gene on Weight Loss and Body Composition under Sibutramine Therapy in Obesity. Clinical Pharmacology: Advances and Applications 2: 105-110.
 
21. Eugene Lin, Po See Chen, Yen Kuang Yang, I-Hui Lee, Tzung-Lieh Yeh, Po-Wu Gean, and Ru-Band Lu. (2010) Modeling Short-Term Antidepressant Responsiveness with Artificial Neural Networks. Open Access Bioinformatics 2: 55-60.
 
22. Hsien-Yuan Lane, Guochuan E. Tsai, and Eugene Lin. (2010) Research Highlights from the Latest Articles in 5-HTTLPR Pharmacogenomics. Personalized Medicine 7(2): 139-141.
 
23. Tun-Jen Hsiao, Lawrence Shih-Hsin Wu, Yuchi Hwang, Shih-Yi Huang, and Eugene Lin. (2010) Effect of the Common G-866A Polymorphism of the Uncoupling Protein 2 Gene on Weight Loss and Body Composition under Sibutramine Therapy in an Obese Taiwanese Population. Molecular Diagnosis and Therapy 14(2): 101-6.
 
24. Chang-Hsun Hsieh, Yi-Jen Hung, Dee Pei, Shi-Wen Kuo, Eugene Lin. (2010) Pilot Association Study Between a Common Variant in the Non-Muscle Myosin Heavy Chain 9 (MYH9) Gene and Diabetic Renal Disease in a Taiwanese Population with Type 2 Diabetes. The Application of Clinical Genetics 3: 17-22.
 
25. Eugene Lin and Sen-Yen Hsu. (2009) A Bayesian Approach to Gene-Gene and Gene-Environment Interactions in Chronic Fatigue Syndrome. Pharmacogenomics 10(1):35-42.
 
26. Eugene Lin and Po-See Chen. (2009) Molecular Genetics of Human Personality Traits for Psychiatric, Behavioral, and Substance-Related Disorders. The Open Translational Medicine Journal 1: 1-8.
 
27. Eugene Lin and Sen-Yen Hsu. (2009) Gender Differences and Pharmacogenomics with Antidepressants in Depression. In: Hernandez P and Alonso S, editors. Women and Depression. New York: Nova Science Publishers.
 
28. Eugene Lin, Po See Chen, Hui Hua Chang, Po-Wu Gean, Hsin Chun Tsai, Yen-Kuang Yang, and Ru Band Lu. (2009) Interaction of Serotonin-Related Genes Affects Short-Term Antidepressant Response in Major Depressive Disorder. Progress in Neuro-Psychopharmacology & Biological Psychiatry 33(7): 1167-72.
 
29. Eugene Lin, Dee Pei, Yi-Jen Huang, Chang-Hsun Hsiehand Lawrence Shih-Hsin Wu. (2009) Gene-Gene Interactions among Genetic Variants from Obesity Candidate Genes for Non-Obese and Obese Populations in Type 2 Diabetes. Genetic Testing and Molecular Biomarkers 13(4): 485-93.
 
30. Eugene Lin, Chen-Jee Hong, Jen-Ping Hwang, Ying-Jay Liou, Chen-Hong Yang, Daniel Cheng, and Shih-Jen Tsai. (2009) Gene-Gene Interactions of the Brain-Derived Neurotrophic-Factor and Neurotrophic Tyrosine Kinase Receptor 2 Genes in Geriatric Depression. Rejuvenation Research 12(6): 387-93.
 
31. Eugene Lin, Cherry Guan-Ju Lin, Jiu-Yao Wang, Lawrence Shih-Hsin Wu. (2009) Gene-Gene Interactions among Genetic Variants from Seven Candidate Genes with Pediatric Asthma in a Taiwanese Population.Current Topics in Genetics 3: 83-88.
 
32. Lung-Cheng Huang, Sen-Yen Hsu, and Eugene Lin. (2009) A Comparison of Classification Methods for Predicting Chronic Fatigue Syndrome Based on Genetic Data. Journal of Translational Medicine 7:81.
 
33. Dun-Jen Hsiao, Lawrence Shih-Hsin Wu, Shih-Yi Huang, Eugene Lin. (2009) Weight Loss and Body Fat Reduction Under Sibutramine Therapy in Obesity with the C825T Polymorphism in the GNB3 Gene.Pharmacogenetics and Genomics 19(9): 730-3.
 
34. Lawrence Shih-Hsin Wu, Chang-Hsun Hsieh, Dee Pei, Yi-Jen Hung, Shi-Wen Kuo, and Eugene Lin. (2009) Association and Interaction Analyses of Genetic Variants in ADIPOQ, ENPP1, GHSR, PPARg, and TCF7L2 Genes for Diabetic Nephropathy in a Taiwanese Population with Type 2 Diabetes. Nephrology Dialysis Transplantation 24(11):3360-6.
 
35. Jiu-Yao Wang, Ya-Huei Liou, Ying-Jye Wu, Ya-Hsin Hsiao, and Lawrence Shih-Hsin Wu. (2009) An Association Study of 13 SNPs from 7 Candidate Genes with Pediatric Asthma in Taiwanese Population. Journal of Clinical Immunology 29(2): 205-9.
 
36. Jiu-Yao Wang, Shyh-Dar Shyur, WH Wang, Ya-Huei Liou, Cherry Guan-Ju Lin, Ying-Jye Wu, and Lawrence Shih-Hsin Wu. (2009) The Polymorphisms of Interleukin 17A (IL-17A) Gene and Its Association with Pediatric Asthma in Taiwanese Population. Allergy 64: 1056-1060.
 
37. Tsen-Fang Tsai, Chih-Hsun Yang, Chia-Yu Chu, Ya-Huei Liou, Wen-Chin Hsiao, Chien-Ting Lin and LawrenceShih-Hsin Wu. (2009) Polymorphisms of MTHFR Gene Associated with Livedoid Vasculopathy in Taiwanese Population. J Dermatol Sci. 54: 214-216.
 
38. Eugene Lin and Po-See Chen. (2008) Pharmacogenomics with Antidepressants in the STAR*D Study.Pharmacogenomics 9 (7): 935-946.
 
39. Eugene Lin and Lung-Cheng Huang. (2008) Identification of Significant Genes in Genomics Using Bayesian Variable Selection Methods. Advances and Applications in Bioinformatics and Chemistry 1: 13–18.
 
40. Eugene Lin and Yuchi Hwang. (2008) A Support Vector Machine Approach to Assess Drug Efficacy of Interferon and Ribavirin Combination Therapy.  Molecular Diagnosis & Therapy 12 (4): 219-223.
 
41. Eugene Lin, Po-See Chen, Lung-Cheng Huang, and Sen-Yen Hsu. (2008) Association Study of a Brain-Derived Neurotrophic-Factor Polymorphism and Short-Term Antidepressant Response in Major Depressive Disorders. Pharmacogenomics and Personalized Medicine 1: 1–6.
 
42. Shyh-Dar Shyur, Jiu-Yao Wang, Cherry Guan-Ju Lin, Ya-Hsin Hsiao, Ya-Huei Liou, Ying-Jye Wu, and Lawrence Shih-Hsin Wu. (2008) The Polymorphisms of Protein-Tyrosine Phosphatase Receptor-Type Delta Gene and Its Association with Pediatric Asthma in the Taiwanese Population. European Journal of Human Genetics 16: 1283-1288.
 
43. Pei-Jer Chen, Yuchi Hwang, Cherry Guan-Ju Lin, Ying-Jye Wu, and Lawrence Shih-Hsin Wu. (2008) The Genetic Differences with Whole Genome Linkage Disequilibrium Mapping Between Responder and Non-responder in Interferon α and Ribavirin Combined Therapy for Chronic Hepatitis C Patients. International Journal of Immunogenetics 35(2): 153-7.
 
44. Loh EW, Tzeng RF, Liu SI, Lawrence Shih-Hsin Wu, Chen ST, Yu YH, Li PC, Chern SR, Lee PY, Lan TH. (2008) High Proportion of Single CYP2D6 Gene Deletion in Chinese Attention-Deficit/Hyperactivity Disorder Children and Its Risk in Oppositional Defiant Disorder. Psychiatry and Clinical Neurosciences 62:749.
 
45. Shih-Wei Lee, Jiu-Yao Wang, Yuan-Chun Hsieh, Ying-Jye Wu, Hsien-Wei Ting, Lawrence Shih-Hsin Wu. (2008) Single Nucleotide Polymorphisms of MD-1 Gene Associated with Pediatric and Adult Asthma in Taiwanese Population. J Micorbiol Immunol Infect 41: 445-449.
 
46. Eugene LinYuchi Hwang, and Ellson Y. Chen. (2007) Gene-Gene and Gene-Environment Interactions in Interferon Therapy for Chronic Hepatitis C. Pharmacogenomics 8 (10): 1327-1335.
 
47. Eugene LinYuchi Hwang, Kung-Hao Liang, and Ellson Y. Chen. (2007) Pattern-Recognition Techniques with Haplotype Analysis in Pharmacogenomics. Pharmacogenomics 8 (1): 75-83.
 
48. Jiu-Yao Wang, Cherry Guan-Ju Lin, Ya-Hsin Hsiao, Ya-Huei Liou, and Lawrence Shih-Hsin Wu. (2007) Single Nucleotide Polymorphisms and Haplotype of MD-1 Gene Associated with High Serum IgE Phenotype with Mite-Sensitive in Taiwanese Children. International Journal of Immunogenetics 34: 407–412.
 
49. Kung-Hao Liang and Ying-Jye Wu. (2007) Prediction of Complex Traits Based on the Epistasis of Multiple Haplotypes. J Hum Genet 52(5): 456-463.
 
50. Zhong-Zheng Zhu, Ai-Zhong Wang, Hang-Ruo Jia, Xia-Xiang Jin, Xiang-Lei He, Li-Fang Hou, and Guanshan Zhu. (2007) Association of the TP53 Codon 72 Polymorphism with Colorectal Cancer in a Chinese Population. Jpn J Clin Oncol 37(5): 385–390.
 
51. Min-Ji Charng, Kuan-Rau Chiou, Hua-Mei Chang, Hao-Ming Cheng, Zhong-Xuan Ye, and Shing-Jong Lin. (2006)Identification and Characterization of LDLR Mutations in Patients with Familial Hypercholesterolemia in TaiwanEuropean Journal of Clinical Investigation 36: 866–874.
 
52. Pei-Jer Chen, Cherry Guan-Ju Lin, Felicia Yi-Fang Lin, Ellson Chenand Lawrence Shih-Hsin Wu. (2006)Genetic Structure Difference between Responder and Non-Responder of Interferon Therapy for Chronic Hepatitis B Patients. J Hum Genet 51(11): 915-1036.
 
53. Chang-Hsun Hsieh, Kung-Hao Liang, Yi-Ren Hung, Li-Chin Huang, Dee Pei, Ya-Tang Liao, Shi-Wen Kuo, Monica Shian-Jy Bey, Jui-Lin Chen, and Ellson Y. Chen. (2006) Analysis of Epistasis for Diabetic Nephropathy among Type 2 Diabetic Patients. Human Molecular Genetics 15: 2701-2708.
 
54. Yuchi HwangEllson Y Chen, Z. John Gu, Wan-Long Chuang, Ming-Lung Yu, Ming-Lung Lai, You-Chen Chao, Chuan-Mo Lee, Jing-Houng Wang, Chia-Yen Dai, Monica Shian-Jy Bey, Ya-Tang Liao, Pei-Jer Chen, and Ding-Shinn Chen. (2006) Genetic Predisposition of Responsiveness to Therapy for Chronic Hepatitis C.Pharmacogenomics 7(5): 697-709.
 
55. Yuchi Hwang, Chunlin Su, Ding-Shinn Chen and Pei-Jer Chen. (2006) Prospect of Individualized Medicine in Chronic Hepatitis C Therapy by Pharmacogenomics.  Current Pharmacogenomics 4(2): 157-167.
 
56. Eugene LinYuchi Hwang, and Chi-Meng Tzeng. (2006) A Case Study of the Utility of the HapMap Database for Pharmacogenomic Haplotype Analysis in the Taiwanese Population. Molecular Diagnosis & Therapy 10(6): 367-370.
 
57. Eugene LinYuchi HwangShu-Ching Wang, Z. John Gu, and Ellson Y. Chen. (2006) An Artificial Neural Network Approach to the Drug Efficacy of Interferon Treatments. Pharmacogenomics 7 (7): 1017-1024.
 
58. Ya-Huei Liou, Chien-Ting Lin, Ying-Jye Wu, and Lawrence Shih-Hsin Wu (2006). The High Prevalence of the Poor and Ultrarapid Metabolite Alleles of CYP2D6, CYP2C9, CYP2C19, CYP3A4, and CYP3A5 in Taiwanese Population. J Hum Genet 51: 59-67.
 
59. Kung-Hao LiangYuchi Huang, Wan-Ching Shao, and Ellson Y. Chen. (2006) An Algorithm for Model Construction and its Applications to Pharmacogenomic Studies. J Hum Genet 51: 751-759.
 
60. Bin Jiang, Zhongzheng Zhu, Feng Liu, Lifang Hou, John Gu, Ellson Y. Chen, Chi-Meng Tzeng, and Guan-Shan Zhu. (2006) Prevalence of Mutation in the Epidermal Growth Factor Receptor Gene in Chinese Patients with Non-Small Cell Lung Cancer. Clinical Oncology 18(8): 635.
 
61. Fernando Scaglia, Chang-Hung Hsu, Haeyoung Kwon, Ren-Kui Bai,, Cherng-Lih Perng, Hua-Mei Chang, Pu Dai, E. O’Brian Smith, David A.H. Whiteman, Annette Feigenbaum, Andrea Gropman, and Lee-Jun C. Wong. (2006) Molecular Bases of Hearing Loss in Multisystemic Mitochondrial Cytopathy. Genetics in Medicine 8(10): 641-652.
 
62. Jih-Shyun Su, Ting-Fen Tsai, Hua-Mei Chang, Kun-Mao Chao, Tsung-Sheng Su, and Shih-Feng Tsai. (2006) Distant Upstream HNF1 Site Regulates Human Class I ADH Gene Expression in the Transgenic Mice. J. Biol. Chem. 281: 19809-19821.
 
63. Choon-Yee Tang, Chia-Fan Liu, Lawrence Shih-Hsin Wu, Yi-Lin Chen, Wen-Tsan Chang, and Jiu-Yao Wang. (2006) Association of CD14 Promoter Polymorphisms and Soluble CD14 Levels in Mite Allergen Sensitization of Children in Taiwan. J Hum Genet 51: 59-67.
 
64. Lawrence Shih-Hsin Wu, Choon-Yee Tang, Ling-Mei Wang, Cherry Guan-Ju Lin, and Jiu-Yao Wang. (2006) Promoter Polymorphism of the Platelet-Derived Growth Factor a-Receptor (PDGFRa) Gene is Associated with the Severity and Allergic Status of Childhood Asthma. International Archives of Allergy and Immunology 141(1): 37-46.
 
65. Lawrence Shih-Hsin Wu. (2006) Construction of Evolutionary Tree Models for Nasopharyngeal Carcinoma Using Comparative Genomic Hybridization Data. Cancer Genet Cytogenet 168: 105-108.
 
66. Jiu-Yao Wang, Cherry Guan-Ju Lin, Monica Shian Jy Bey, Ling-Mei Wang, Felicia Yi-Fang Lin, Lichih Huang, and Lawrence Shih-Hsin Wu. (2005) Discovery of Genetic Difference between Asthmatic Children with High IgE Level and Normal IgE Level by Whole Genome Linkage Disequilibrium Mapping Using 763 Autosomal STR Markers. J Hum Genet 50: 249-258.
 
67. Jiu-Yao Wang, Ling-Mei Wang, Cherry Guan-Ju Lin, Ashley Ching-Wei Chang, and Lawrence Shih-Hsin Wu. (2005) Association Study Using Combination Analysis of SNP and STRP Markers: CD14 Promoter Polymorphism and IgE Level in Taiwanese Asthma Children. J Hum Genet 50: 36-41.
 
68. Chi-Yuan Chou, Yi-Ling Lin, Yu-Chyi Huang, Sheh-Yi Sheu, Ta-Hsien Lin, Huey-Jen Tsay, Gu-Gang Chang, and Ming-Shi Shiao. (2005) Structural Variation in Human Apolipoprotein e3 and e4: Secondary Structure, Tertiary Structure, and Size Distribution. Biophys J. 88(1): 455-466.
 
69. Bin Jiang, Guan-Shan Zhu, Feng Liu, Sheng-Ji Gong, Bao-Di Yao, Lei Zhong, Zhong-Zheng Zhu, and Eric Tzeng. (2005) Mutational Analysis of EGFR in Chinese Patients with Non-Small Cell Lung Cancer. Academic Journal of Shanghai Second Medical University 25(11): 1148-1150, Chinese.
 
70. Zhong-Zheng Zhu, Wen-Ming Cong, Shu-Fang Liu, Zhi-Hong Xian, Wei-Qing Wu, Meng-Chao Wu, Bin Gao, Li-Fang Hou, and Guan-Shan Zhu. (2005) A p53 Polymorphism Modifies the Risk of Hepatocellular Carcinoma among Non-Carriers but not Carriers of Chronic Hepatitis B Virus Infection. Cancer Letters 229: 77–83.
 
71. Zhong-Zheng Zhu, Wen-Ming Cong , Guan-Shan Zhu, Shu-Fang Liu, Zhi-Hong Xian, Wei-Qing Wu , Xiu-Zhong Zhang , Yan-Hua Wang , Meng-Chao Wu (2005) Association of p53 Codon 72 Polymorphism with Genetic Susceptibility to Hepatocellular Carcinoma in Chinese Population. Chin J Med Genet 22 (6): 76-79, Chinese.
 
72. Zhong-Zheng Zhu, Wen-Ming Cong , Shu-Fang Liu, Hui Dong, Guan-Shan Zhu, Meng-Chao Wu (2005) p53 Gene Codon 72 Polymorphism and Genetic Susceptibility to Hepatocellular Carcinoma in Chinese Population. Natl Med J China 85 (12): 632-635, Chinese.
 
73. Cheng-Hsin Lu, Cherry Guan-Ju Lin, Lichih Huang, Ling-Mei Wang, and Lawrence Shih-Hsin Wu. (2004) Heterozygosities and Allelic Frequencies of 811 Dinucleotide-Repeat Marker Loci in the Taiwanese Population. J Hum Genet 49: 325-333.
 
74. Xintai Zhao, Jinjun Li, Yinghua He, Fei Lan, Lili Fu, Jianying Guo, Ruijiao Zhao, Yun YeMei He, Wenming Chong, Jianguo Chen, Lisheng Zhang, Nanwu Yang, Binghua Xu, Mengchao Wu, Dafang Wan, and Jian-ren Gu. (2001) A Novel Growth Suppressor Gene on Chromosome 17p13.3 with a High Frequency of Mutation in Human Hepatocellular Carcinoma. Cancer Research 61: 7383–7387.
 
Acknowledgement Articles
 
1. Yue-Ie C. Hsing, Chyr-Guan Chern, Ming-Jen Fan, (another 26 authors), and Su-May Yu (2007) A rice gene activation/knockout mutant resource for high throughput functional genomics. Plant Molecular Biology 63 (3): 351-64.
 
2. Chyr-Guan Chern, Ming-Jen Fan, Su-May Yu, (another 19 authors), and Yue-Ie C. Hsing (2007). A rice phenomics study—Phenotype scoring and seed propagation of a T-DNA insertion-induced rice mutant population.Plant Molecular Biology 65 (4): 427-38.
 
 
Meeting abstracts since 2004
 
Eugene Lin. (2011) Pharmacogenomics of Antipsychotics in a Context of Gene-Gene Interactions. World Psychiatric Association Regional Meeting, Taiwan, November 2011.
 
Sen-Yen Hsu, Lung-Cheng Huang, and Eugene Lin*. (2008) Pharmacogenetics Study of a Brain-Derived Neurotrophic-Factor Polymorphism and Antidepressant Response in Major Depression in Taiwan. The 47th Annual Meeting of Taiwanese Society of Psychiatry, Taiwan, November 2008.
 
Eugene Lin(2008) Molecular Genetics of Human Personality Traits on the Serotonin Transporter Gene.Taiwan Human Genetics Society Conference, Taiwan, October 2008.
 
Eagen Chao, John Gu, and Ellson Chen. (2007) The Era of Personalized Medicine.  HUGO Mutation Detection 2007: IX International Symposium on Mutations in the Genome, China, September 2007.
 
Eugene Lin and Yuchi Hwang. (2007) A Bayesian Method for Gene-Gene and Gene-Environment Interactions in Pharmacogenomics. The Taipei International Statistical Symposium and ICSA International Conference, Taiwan, June 2007.
 
Eugene Lin and Yuchi Hwang. (2007) A Fuzzy Neural Network Algorithm for Pharmacogenomics Studies.Asia-Pacific Bioinformatics Conference (APBC2007), Hong Kong, January 2007.
 
Po-See Chen, Yen-Kuang Yang, I-Hui Lee, Eugene Lin, Kao-Ching Chen, Tzung-Lieh Yeh, and Ru-Band Lu. (2006) Pharmacogenomics Study of a Tryptophan Hydroxylase Polymorphism and Major Depressive Disorders in Taiwan. Taiwanese Society of Psychiatry Conference, Taiwan, November 2006.
 
Kung-Hao LiangYuchi Hwang, and Ellson Y. Chen. (2006) The Construction of Pharmacogenomic Models Using the Methodology of Genetic Algorithm. Joint Human Genome Organization Pacific Meeting and Asia-Pacific Human Genetics Conference (HUGO-AP 2006), Taiwan, March 2006.
 
Eugene Lin, Po-See Chen, Yen-Kuang Yang, I-Hui Lee, Tzung-Lieh Yeh, and Ru-Band Lu. (2006) An Artificial Neural Network Algorithm for Modeling Antidepressant Responsiveness with Single Nucleotide Polymorphisms.  Asia Pacific EBM Network Conference, Hong Kong, December 2006.
 
Eugene Lin and Yuchi Hwang. (2006) A Preliminary Study of Candidate Genes for AntidepressantEfficacy. Taiwan Association Against Depression Conference, Taiwan, December 2006.
 
Eugene Lin and Yuchi Hwang (2006) A Pattern Recognition Approach to Predict the Drug Efficacy of Interferon Treatments. Symposium and Workshop of Bioinformatics in Taiwan 2006, Taiwan, September 2006.
 
Eugene Lin, Po-See Chen, Yen-Kuang Yang, I-Hui Lee, Kao-Ching Chen, Tzung-Lieh Yeh, and Ru-Band Lu. (2006) Comparisons of Taiwanese and Four Populations in HapMap Database Based on SNPs of AntidepressantEfficacy Related Genes. Evolutionary Genomics and Bioinformatics Symposium and Workshop, Taiwan, August 2006.
 
Eugene Lin, Cheng-Yan Lee, and Yuchi Hwang. (2006) A Pharmacogenomics Approach with Genetic Databases for the Drug Efficacy of Antidepressants. Joint Human Genome Organization Pacific Meeting and Asia-Pacific Human Genetics Conference (HUGO-AP 2006), Taiwan, March 2006.
 
Eugene Lin and Yuchi Hwang. (2006) A Fuzzy Expert System for the Inference of Antidepressants Based on Gene Polymorphisms. Asia-Pacific Bioinformatics Conference (APBC2006), Taiwan, February 2006.
 
Yuchi HwangEugene Lin, Ya-Tang Liao, Monica Shian-Jy Bey, Chun-Lin Su, Ding-Shinn Chen, Pei-Jer Chen and Ellson Y. Chen. (2005) The Benefits of Pharmacogenomics for Hepatitis Therapy. HVIII HUGO International Symposium on Mutation Detection in the Genome, Greece, June 2005.
 
Yuchi HwangEugene Lin, Ya-Tang Liao, Monica Shian-Jy Bey, Chun-Lin Su, Ding-Shinn Chen, Pei-Jer Chen and Ellson Y. Chen. (2005) The Benefits of Pharmacogenomics for Hepatitis Therapy. HUGO's 10th Human Genome Meeting Kyoto, Japan, April 2005.
 
Eugene Lin, Cheng-Yan Lee, and Yuchi Hwang. (2005) A Pharmacogenomics Approach to Assess the Drug Efficacy of Antidepressants. Taiwan Association Against Depression Conference, Taiwan, December 2005.
 
Eugene Lin, Cheng-Yan Lee, and Yuchi Hwang. (2005) A Pharmacogenomics Approach with Genetic Databases for the Drug Efficacy of Antidepressants. International Symposium on New Drug Development, Taiwan, December 2005.
 
Eugene Lin and Yuchi Hwang. (2005) The Selection of SNPs for the Drug Efficacy of Antidepressants Using a Pharmacogenomics Approach with Genetic Databases. The Symposium and Workshop of Bioinformatics in Taiwan, Taiwan, September 2005.
 
Eugene Lin, Chienwei Tsai, and Yuchi Hwang. (2005) Association Studies for Depression and Genes Using a Statistical Approach with Genetic Databases. Taipei Symposium on Medical Statistics (TSMS), Taiwan, June 2005.
 
Eugene Lin, Dennis Chen, Shih-Hsin Wu, and Z. John Gu. (2005) A Prediction Model for Allergic and Non-Allergic Asthma Based on Single Nucleotide Polymorphisms. Asia-Pacific Bioinformatics Conference (APBC2005), Singapore, January 2005.
 
Ellson Y. Chen and Ding-Shinn Chen. (2004) Pharmacogenomics Approach to Select CHC Patients Who May Respond to IFN Combination Therapy. Asian Pacific Association for the Study of the Liver, India, December 2004.
 
Ellson Y. Chen and Ding-Shinn Chen. (2004) Pharmacogenomics Approach to Select CHC Patients Who May Respond to IFN Combination Therapy. American Association for the Study of Liver Diseases, Boston, October 2004.
 
Ellson Y. Chen. (2004) SNP and Gene Expression Profiling to Predict Clinical Outcomes of Interferon Treatment for HCV Patients - A Pharmacogenomic Approach. International Liver Congress, Hong Kong, February 2004. pp. 92.
 
Kuang-Den Chen et al. (2004) Human SNP Genotypes to Predict Clinical Outcomes of Interferon Treatment for Chronic Hepatitis C Patients. AASLD American Association of Study Liver Diseases, Boston, U.S.A.2004.
 
John Gu et al. (2004) Patient Selection Through a PhGX Approach. The Second International Conference on Pharmacogenomics, New York, U.S.A. 2004.
 
Yuchi Hwang et al. (2004) A New Algorithm for Construction Genetic Prediction Model by SNPs. Taipei Symposium Statistical Genomics, 2004.
 
Yuchi Hwang, Kuang-Den Chen, Ching-Wei Chang and Jui-Lin Chen. (2004) SNP Genotype Modeling - Pharmacogenomic Approach for Studying Hepatitis C Treatment. International Liver Congress, Hong Kong, February 2004. pp. 96–97.
 
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